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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913481Generated: October 27, 2026

2,5-Difluorobenzohydrazide → 1-{[5-(2,5-Difluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913481

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-DifluorobenzohydrazideHCID 2774074—
Reactant[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acidHCID 57800132—
Product1-{[5-(2,5-Difluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 57800271—

Reaction Steps

Synthesized as described in Example 35C from [5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid and 2,5-difluorobenzohydrazide: MS (ES) m/z 405 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-d3720aecefd543c1ab8bcba1545b0ffd
Source noteuspto-grants-2011_09