HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → 1-(Cyclopropylmethyl)-2-methyl-4-(trifluoromethyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 2-methyl-4-(trifluoromethyl)-1H-indole | HCID 19697022 | — |
| Product | 1-(Cyclopropylmethyl)-2-methyl-4-(trifluoromethyl)-1H-indole | HCID 57800127 | — |
Reaction Steps
Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole and (bromomethyl)cyclopropane: 1H NMR (400 MHz, CDCl3) δ 7.45 (d, J=8.2 Hz, 1H), 7.35 (d, J=8.2 Hz, 1H), 7.16 (t, J=8.2 Hz, 1H), 6.45 (s, 1H), 4.02 (d, J=6.4 Hz, 2H), 2.48 (s, 3H), 1.18 (m, 1H), 0.56 (m, 2H), 0.34 (m, 2H); MS (ES) m/z 254 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026262B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-bb75c547577b4e779cb9180dba78cbcd |
| Source note | uspto-grants-2011_09 |