2-Bromoacetamide → HCID 67404352, compound

HRID 913504Notes

Reaction equation

HRID 913504 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.Br[CH2:18][C:19]([NH2:21])=[O:20]>>[C:15]([C:7]1[C:8]([C:11]([F:12])([F:14])[F:13])=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]([CH2:18][C:19]([NH2:21])=[O:20])[C:2]([CH3:1])=[CH:10]2)#[N:16]

Participants

3

Reactant 2

HCID 696322-BromoacetamideHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 67404352HCID 67404352, compound

Procedure

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 2-bromoacetamide: 1H NMR (400 MHz, DMSO-d6) δ 7.82 (d, J=8.5 Hz, 1H), 7.71 (bs, 1H), 7.67 (d, J=8.5 Hz, 1H), 7.35 (bs, 1H), 6.55 (s, 1H), 4.89 (s, 2H), 2.39 (s, 3H); MS (ES) m/z 282 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-d8e51092c1984a4dba83893631145953
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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