3-(Trifluoromethyl)benzoyl chloride → HCID 57800156, compound

HRID 913527Notes

Reaction equation

HRID 913527 reaction equation
[C:1]([C:3]1[C:4]([C:20]([F:23])([F:22])[F:21])=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH:12]([CH3:18])/[C:13](=[N:16]/[H])/[NH:14][OH:15])[C:7]([CH3:19])=[CH:6]2)#[N:2].[F:24][C:25]([F:36])([F:35])[C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][CH:34]=1)[C:29](Cl)=O>>[CH3:19][C:7]1[N:8]([CH:12]([C:13]2[N:16]=[C:29]([C:28]3[CH:32]=[CH:33][CH:34]=[C:26]([C:25]([F:24])([F:35])[F:36])[CH:27]=3)[O:15][N:14]=2)[CH3:18])[C:9]2[C:5]([CH:6]=1)=[C:4]([C:20]([F:23])([F:22])[F:21])[C:3]([C:1]#[N:2])=[CH:11][CH:10]=2

Participants

3

Reactant 2

HCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 178506522HCID 178506522, compound

Product 1

HCID 57800156HCID 57800156, compound

Procedure

Synthesized as described in Example 32B from (1Z)-2-[5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxypropanimidamide and 3-(trifluoromethyl)benzoyl chloride: MS (ES) m/z 465 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-b14be9b0fcb64d3a90a9e1a4fbcf2644
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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