3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole → 2-Cyclopropyl-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole	HCID 43120209	—
Reactant	2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile	HCID 67404472	—
Product	2-Cyclopropyl-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile	HCID 67406357	—

Reaction Steps

Synthesized as described in Example 4 using 2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, CDCl3) δ 7.67 (d, J=8.5 Hz, 1H), 7.57 (m, 3H), 7.05 (t, J=8.5 Hz, 1H), 6.48 (s, 1H), 5.64 (s, 2H), 2.13 (m, 1H), 1.15 (m, 2H), 0.92 (m, 2H); MS (ES) m/z 445 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026262B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-f0b548d037e14f71850c74880c9cc74b
Source note	uspto-grants-2011_09