Bromomethylcyclopropane → 1-(Cyclopropylmethyl)-2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	Bromomethylcyclopropane	HCID 81503	—
Reactant	2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile	HCID 67405196	—
Product	1-(Cyclopropylmethyl)-2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile	HCID 67405485	—

Reaction Steps

Synthesized as described in Example 4 using 2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile and (bromomethyl)cyclopropane. 1H NMR (400 MHz, CDCl3) δ 7.50 (d, J=9.2 Hz, 1H), 7.48 (d, J=9.2 Hz, 1H), 6.56 (d, J=1.7 Hz, 1H), 4.05 (d, J=6.6 Hz, 2H), 2.67 (t, J=7.1 Hz, 2H), 2.07 (m, 1H), 1.15 (m, 1H), 1.03 (d, J=6.6 Hz, 6H), 0.58 (m, 2H), 0.35 (m, 2H); MS (ES) m/z 321 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026262B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-63b19bdefda640469401dd5a0929cbb7
Source note	uspto-grants-2011_09