HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913569Generated: October 25, 2026
5-bromo-4-chloro-2-ethyl-1H-benzimidazole → 4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile
https://huagongshe.com/reaction/913569
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-bromo-4-chloro-2-ethyl-1H-benzimidazole | HCID 57800158 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile | HCID 67404902 | 35.5% |
Reaction Steps
5-Bromo-4-chloro-2-ethyl-1H-benzimidazole (0.050 g, 0.192 mmol) and CuCN (0.030 g, 0.576 mmol) were combined in NMP (3 mL) and heated to 220° C. for 20 min in a microwave. The cooled mixture was partitioned between Et2O and water. The organic portion was washed with brine, dried (Na2SO4), filtered, and concentrated in vacuo. Purification (SiO2, EtOAc/hexanes) afforded the title compound (0.014 g): MS (ESI) m/z 206 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08026262B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-726f7b16115b4859b4127be5efff1667 |
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| Source note | uspto-grants-2011_09 |
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