反应详情

A CH2Cl2 (15 mL) solution of 4-chloro-5-(methyloxy)-1-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)-1H-benzimidazole (0.14 g, 0.422 mmol) at rt was treated dropwise with BBr3 (1M CH2Cl2, 1.055 ml, 1.055 mmol) and stirred for 2 h. The mixture was quenched with saturated aqueous NaHCO3, adjusted to a pH of 7, and extracted with CH2Cl2. The combined organic portions were washed combined with brine, dried over Na2SO4, filtered, and concentrated in vacuo. Purification (SiO2; EtOAc/hexanes) afforded the title compound (0.103 g): MS (ESI) m/z 319 (M+1).

1. customThe mixture was quenched with saturated aqueous NaHCO3
2. extractionextracted with CH2Cl2
3. washThe combined organic portions were washed
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customPurification (SiO2; EtOAc/hexanes)