3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole → 4-Chloro-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole	HCID 43120209	—
Reactant	4-chloro-2-propyl-1H-indole-5-carbonitrile	HCID 67404338	—
Product	4-Chloro-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-5-carbonitrile	HCID 57800072	—

Reaction Steps

Synthesized as described in Example 4 from 4-chloro-2-propyl-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 7.95 (s, 1 H), 7.80-7.61 (m, 4 H), 7.57 (d, J=8.5 Hz, 1 H), 5.83 (s, 2 H), 3.05-2.75 (m, 2 H), 1.70-1.41 (m, 2 H), 0.92 (t, J=7.3 Hz, 3 H); MS (ES) m/z 413 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026262B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-ab8e52478c4f46e7aea996d668c238ed
Source note	uspto-grants-2011_09