HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isocyanate → 1-(6-Ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 2-Aminobenzothiazole-6-carboxylate | HCID 601008 | — |
| Reactant | 1-(6-Benzyl-2-benzothiazolyl)-3-ethylurea | HCID 21985614 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(6-Ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea | HCID 21985580 | 82% |
Reaction Steps
According to the General Procedure for 1-(6-substituted-2-benzothiazolyl)-3-ethylurea compounds, and similar to the synthesis of 1-(6-benzyl-2-benzothiazolyl)-3-ethylurea, a mixture of 2-amino-6-ethoxycarbonyl-benzothiazole, triethylamine and ethyl isocyanate in toluene was reacted to give the desired compound 2.40 g (82%). LC/MS 294.0 (M+1); LC retention time 4.29 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091227B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-193af041f89c4a718cbabf830a9304dc |
| Source note | uspto-grants-2006_08 |