HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole → 4-Chloro-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-methyl-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole | HCID 43120209 | — |
| Reactant | 4-chloro-2-methyl-1H-indole-5-carbonitrile | HCID 67404878 | — |
| Product | 4-Chloro-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-methyl-1H-indole-5-carbonitrile | HCID 57800117 | — |
Reaction Steps
Synthesized as described in Example 4 from 4-chloro-2-methyl-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 7.94 (d, J=1.1 Hz, 1 H), 7.81 (d, J=8.7 Hz, 1 H), 7.75-7.71 (m, 2 H), 7.69-7.63 (m, 1 H), 7.58 (dd, J=8.7, 1.5 Hz, 1 H), 5.83 (s, 2 H), 2.47 (s, 3 H); MS (ES) m/z 385 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026262B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-99bf9ba265334220842be706764444fe |
| Source note | uspto-grants-2011_09 |