5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole → 1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-propyl-1H-indole-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole	HCID 2780957	—
Reactant	4-chloro-2-propyl-1H-indole-5-carbonitrile	HCID 67404338	—
Product	1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-propyl-1H-indole-5-carbonitrile	HCID 57800398	—

Reaction Steps

Synthesized as described in Example 4 from 4-chloro-2-propyl-1H-indole-5-carbonitrile and 5-[3,5-bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 8.53 (s, 2 H), 8.50 (s, 1 H), 7.96 (s, 1 H), 7.77 (d, J=8.7 Hz, 1 H), 7.59 (d, J=8.7 Hz, 1 H), 5.87 (s, 2 H), 2.97-2.82 (m, 2 H), 1.70-1.56 (m, 2 H), 0.97-0.89 (m, 3 H); MS (ES) m/z 513 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026262B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-db9ab2987b63447c94a4f6321212d546
Source note	uspto-grants-2011_09