N-(4-(2-Bromoethoxy)phenyl)acetamide → N-(4-{[2-(4-Chloro-5-cyano-2-propyl-1H-indol-1-yl)ethyl]oxy}phenyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	N-(4-(2-Bromoethoxy)phenyl)acetamide	HCID 6483715	—
Reactant	4-chloro-2-propyl-1H-indole-5-carbonitrile	HCID 67404338	—
Product	N-(4-{[2-(4-Chloro-5-cyano-2-propyl-1H-indol-1-yl)ethyl]oxy}phenyl)acetamide	HCID 57800162	—

Reaction Steps

Synthesized as described in Example 4 from 4-chloro-2-propyl-1H-indole-5-carbonitrile and N-{4-[(2-bromoethyl)oxy]phenyl}acetamide: 1H NMR (400 MHz, DMSO-d6) δ 9.72 (s, 1 H), 7.90 (s, 1 H), 7.80 (d, J=8.5 Hz, 1 H), 7.54 (d, J=8.5 Hz, 1 H), 7.39 (d, J=9.0 Hz, 2 H), 6.71 (d, J=9.0 Hz, 2 H), 4.63 (t, J=4.9 Hz, 2 H), 4.18 (t, J=4.9 Hz, 2 H), 2.82 (t, J=4.9 Hz, 2 H), 1.94 (s, 3 H), 1.73-1.49 (m, 2 H), 0.94 (t, J=4.9 Hz, 3 H); MS (ES) m/z 396 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026262B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-3f9b7beeb4024b4b9f99550d19ef5286
Source note	uspto-grants-2011_09