3-(Chloromethyl)-5-(3,5-dimethylisoxazol-4-yl)-1,2,4-oxadiazole → 4-Chloro-1-{[5-(3,5-dimethyl-4-isoxazolyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	3-(Chloromethyl)-5-(3,5-dimethylisoxazol-4-yl)-1,2,4-oxadiazole	HCID 2735760	—
Reactant	4-chloro-2-propyl-1H-indole-5-carbonitrile	HCID 67404338	—
Product	4-Chloro-1-{[5-(3,5-dimethyl-4-isoxazolyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-5-carbonitrile	HCID 57800112	—

Reaction Steps

Synthesized as described in Example 4 from 4-chloro-2-propyl-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-(3,5-dimethyl-4-isoxazolyl)-1,2,4-oxadiazole 1H NMR (400 MHz, DMSO-d6) δ 7.94 (s, 1 H), 7.75 (d, J=8.5 Hz, 1 H), 7.57 (d, J=8.5 Hz, 1 H), 5.80 (s, 2 H), 2.91 (t, J=4.9 Hz, 2 H), 2.66 (s, 3 H), 2.38 (s, 3 H), 1.71-1.58 (m, 2 H), 0.92 (t, J=7.3 Hz, 3 H); MS (ES) m/z 396 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026262B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-30eb684365444cb68eadf2190091ef80
Source note	uspto-grants-2011_09