5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole → 1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-methyl-1H-indole-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole	HCID 2780957	—
Reactant	4-chloro-2-methyl-1H-indole-5-carbonitrile	HCID 67404878	—
Product	1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-methyl-1H-indole-5-carbonitrile	HCID 57920609	—

Reaction Steps

Synthesized as described in Example 4 from 4-chloro-2-methyl-1H-indole-5-carbonitrile and 5-[3,5-bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 8.54 (s, 2 H), 8.49 (s, 1 H), 7.94 (s, 1 H), 7.83 (d, J=8.5 Hz, 1 H), 7.60 (d, J=8.7 Hz, 1 H), 5.87 (s, 2 H), 2.51 (s, 3 H); MS (ES) m/z 485 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026262B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-c95410996be043b6b78840ad660e4321
Source note	uspto-grants-2011_09