1-(2-Bromoethoxy)-2,4-difluorobenzene → 4-Chloro-1-{2-[(2,4-difluorophenyl)oxy]ethyl}-2-methyl-1H-indole-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Bromoethoxy)-2,4-difluorobenzene	HCID 23294261	—
Reactant	4-chloro-2-methyl-1H-indole-5-carbonitrile	HCID 67404878	—
Product	4-Chloro-1-{2-[(2,4-difluorophenyl)oxy]ethyl}-2-methyl-1H-indole-5-carbonitrile	HCID 57800428	—

Reaction Steps

Synthesized as described in Example 4 from 4-chloro-2-methyl-1H-indole-5-carbonitrile and 1-[(2-bromoethyl)oxy]-2,4-difluorobenzene: 1H NMR (400 MHz, DMSO-d6) δ 7.88 (s, 1 H), 7.76 (d, J=8.7 Hz, 1 H), 7.50 (d, J=8.7 Hz, 1 H), 7.26-7.15 (m, 1 H), 7.10-7.00 (m, 1 H), 6.92-6.88 (m, 1 H), 4.67 (t, J=5.0 Hz, 2 H), 4.30 (t, J=5.0 Hz, 2 H), 3.30 (s, 3 H); MS (ES) m/z 347 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026262B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-320da06382564159a19d389edb0f35dc
Source note	uspto-grants-2011_09