3-Chloro-4,5-difluorobenzoic acid → HCID 57800347, compound

HRID 913638Notes

Reaction equation

HRID 913638 reaction equation
[C:1]([C:3]1[C:4]([C:17]([F:20])([F:19])[F:18])=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13](=[NH:16])[NH:14][OH:15])[CH:7]=[CH:6]2)#[N:2].[Cl:21][C:22]1[CH:23]=[C:24]([CH:28]=[C:29]([F:32])[C:30]=1[F:31])[C:25](O)=O>>[Cl:21][C:22]1[CH:23]=[C:24]([C:25]2[O:15][N:14]=[C:13]([CH2:12][N:8]3[C:9]4[C:5](=[C:4]([C:17]([F:19])([F:20])[F:18])[C:3]([C:1]#[N:2])=[CH:11][CH:10]=4)[CH:6]=[CH:7]3)[N:16]=2)[CH:28]=[C:29]([F:32])[C:30]=1[F:31]

Participants

3

Reactant 2

HCID 149493633-Chloro-4,5-difluorobenzoic acidHCID 178509476HCID 178509476, compound

Product 1

HCID 57800347HCID 57800347, compound

Procedure

Synthesized as described in Example 241 from 2-[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide and 3-chloro-4,5-difluorobenzoic acid: MS (APCl) m/z 440 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-eb0456f8f1c24a8083a74845d2a04f43
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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