3-(Chloromethyl)-5-(4-fluorophenyl)-1,2-oxazole → HCID 67405355, compound

HRID 913647Notes

Reaction equation

HRID 913647 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.Cl[CH2:18][C:19]1[CH:23]=[C:22]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[O:21][N:20]=1>>[F:30][C:27]1[CH:26]=[CH:25][C:24]([C:22]2[O:21][N:20]=[C:19]([CH2:18][N:3]3[C:4]4[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=4)[CH:10]=[C:2]3[CH3:1])[CH:23]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 166414733-(Chloromethyl)-5-(4-fluorophenyl)-1,2-oxazoleHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 67405355HCID 67405355, compound

Procedure

Synthesized in a manner similar to Example 23 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-(4-fluorophenyl)isoxazole: MS (ES) m/z 400 (M+1).

Sources & evidence

ORD record
ord-e4d605460b444495a287c392eb4bcd52
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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