化工社化工社 化学情報印刷レポート · 研究参考用
5-(Chloromethyl)-3-phenylisoxazole → 2-Methyl-1-[(3-phenyl-5-isoxazolyl)methyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(Chloromethyl)-3-phenylisoxazole | HCID 2764057 | — |
| 反応物 | 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 53309346 | — |
| 生成物 | 2-Methyl-1-[(3-phenyl-5-isoxazolyl)methyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67405441 | — |
反応手順
Synthesized in a manner similar to Example 23 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 5-(chloromethyl)-3-phenylisoxazole: 1H NMR (400 MHz, acetone-d6) δ 8.06 (d, J=8.6 Hz, 1H), 7.84-7.80 (m, 2H), 7.69 (d, J=8.4 Hz, 1H), 7.48-7.44 (m, 3H), 6.88 (s, 1H), 6.69 (s, 1H), 5.86 (s, 2H), 2.69 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08026262B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-ce6bd2bfa49b4905b90f91384984ffe7 |
| 出典メモ | uspto-grants-2011_09 |