4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole → HCID 67406114, compound

HRID 913694Notes

Reaction equation

HRID 913694 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.Cl[CH2:18][C:19]1[N:20]=[C:21]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[S:22][CH:23]=1>>[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([C:21]2[S:22][CH:23]=[C:19]([CH2:18][N:3]3[C:4]4[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=4)[CH:10]=[C:2]3[CH3:1])[N:20]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 6102974-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazoleHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 67406114HCID 67406114, compound

Procedure

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole: MS (ES) m/z 432 (M+1) and 434 (M+1, isotope).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-c80ef9ad832a498c8482eb77be602090
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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