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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913695Generated: October 25, 2026

4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole → 2-Methyl-4-(trifluoromethyl)-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913695

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazoleHCID 2736625—
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
Product2-Methyl-4-(trifluoromethyl)-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl)-1H-indole-5-carbonitrileHCID 86620694—

Reaction Steps

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 4-(chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole: MS (ES) m/z 466 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-8c698f31a3894954b3e3eeffffef06a4
Source noteuspto-grants-2011_09