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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913711Generated: October 26, 2026

4-(Trifluoromethyl)phenylboronic acid → 2-Methyl-4-(trifluoromethyl)-1-{[4'-(trifluoromethyl)-3-biphenylyl]methyl}-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913711

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)phenylboronic acidHCID 2734389—
Reactant1-[(3-Bromophenyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405035—
Product2-Methyl-4-(trifluoromethyl)-1-{[4'-(trifluoromethyl)-3-biphenylyl]methyl}-1H-indole-5-carbonitrileHCID 86620703—

Reaction Steps

Synthesized as described in Example 310D using 1-[(3-bromophenyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 318A) and [4-(trifluoromethyl)phenyl]boronic acid: MS (ES) m/z 459 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-1690a66d9ae345a2805209cbcba7bea5
Source noteuspto-grants-2011_09