Carbon Tetrachloride → 3-(Chloromethyl)-5-[3,5-bis(trifluoromethyl)phenyl]isoxazole

Participants

Reaction Conditions

Reaction Steps

To a solution of {5-[3,5-bis(trifluoromethyl)phenyl]-3-isoxazolyl}methanol (Example 323B) (0.100 g, 0.32 mmol) in dry carbon tetrachloride (15 mL) was added PS-triphenylphosphine (0.292 g, 2.2 mmol/g, 0.64 mmol). The reaction was heated at 75° C. overnight. The resin was filtered and washed with carbon tetrachloride. Concentration in vacuo afforded the title compound, which was used for the next step without further purification.

Provenance & Evidence