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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913720Generated: October 31, 2026

2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → 1-({5-[3,5-bis(Trifluoromethyl)phenyl]-3-isoxazolyl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913720

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
Reactant3-(Chloromethyl)-5-[3,5-bis(trifluoromethyl)phenyl]isoxazoleHCID 57800202—
Product1-({5-[3,5-bis(Trifluoromethyl)phenyl]-3-isoxazolyl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 86620707—

Reaction Steps

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 3-(chloromethyl)-5-[3,5-bis(trifluoromethyl)phenyl]isoxazole (Example 323C): MS (ES) m/z 518 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-a105adc83c7441f3845ba599706ba730
Source noteuspto-grants-2011_09