3-Bromo-5-(chloromethyl)isoxazole → HCID 67406096, compound

HRID 913722Notes

Reaction equation

HRID 913722 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.[Br:17][C:18]1[CH:22]=[C:21]([CH2:23]Cl)[O:20][N:19]=1>>[Br:17][C:18]1[CH:22]=[C:21]([CH2:23][N:3]2[C:4]3[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])[O:20][N:19]=1

Participants

3

Reactant 2

HCID 27632033-Bromo-5-(chloromethyl)isoxazoleHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 67406096HCID 67406096, compound

Procedure

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 3-bromo-5-(chloromethyl)isoxazole (Example 325A): MS (ES) m/z 382 (M−1) and 384 (M−1, isotope).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-797282668cf84a3caa85b23734633cb2
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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