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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913725Generated: October 31, 2026

(S)-(+)-2-Chloro-1-propanol → 1-[(1R)-2-Hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913725

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-(+)-2-Chloro-1-propanolHCID 641045—
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
Product1-[(1R)-2-Hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404820—

Reaction Steps

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and (2S)-2-chloro-1-propanol: MS (ES) m/z 283 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-d0fc43eda9534728ad99447f75b778e2
Source noteuspto-grants-2011_09