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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913734Generated: October 31, 2026

Acetaminophen → N-[4-({2-[5-Cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]-1-methylethyl}oxy)phenyl]acetamide

https://huagongshe.com/reaction/913734

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetaminophenHCID 1983—
Reactant1-(2-Hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67403809—
ProductN-[4-({2-[5-Cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]-1-methylethyl}oxy)phenyl]acetamideHCID 67405184—

Reaction Steps

Synthesized as described in Example 139C using 1-(2-hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 335) and N-(4-hydroxyphenyl)acetamide: MS (ES) m/z 414 (M−1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-0b67d5ee335448ab86a5e782f65b5a4d
Source noteuspto-grants-2011_09