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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913748Generated: October 26, 2026

2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → 1-({2-[3,5-bis(Trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913748

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
Reactant2-[3,5-Bis(trifluoromethyl)phenyl]-4-(chloromethyl)-1,3-oxazoleHCID 57800468—
Product1-({2-[3,5-bis(Trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 86620713—

Reaction Steps

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 2-[3,5-bis(trifluoromethyl)phenyl]-4-(chloromethyl)-1,3-oxazole: MS (ES) m/z 518 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-40fd02c2c9ba42fdb9be324afcc02bde
Source noteuspto-grants-2011_09