Bromoacetonitrile → HCID 67404667, compound

HRID 913759Notes

Reaction equation

HRID 913759 reaction equation
[CH:1]1([C:4]2[NH:5][C:6]3[C:11]([CH:12]=2)=[C:10]([C:13]([F:16])([F:15])[F:14])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=3)[CH2:3][CH2:2]1.Br[CH2:20][C:21]#[N:22]>>[C:21]([CH2:20][N:5]1[C:6]2[C:11](=[C:10]([C:13]([F:14])([F:15])[F:16])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=2)[CH:12]=[C:4]1[CH:1]1[CH2:2][CH2:3]1)#[N:22]

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 674044722-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 67404667HCID 67404667, compound

Procedure

Synthesized as described in Example 62 using 2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 165A) and bromoacetonitrile: MS (ES) m/z 290 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-8dd426aa94b348b8b5c325907c764f61
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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