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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913764Generated: October 30, 2026

2-(Trifluoromethyl)pyridine-4-carboxylic acid → 2-Cyclopropyl-4-(trifluoromethyl)-1-({5-[2-(trifluoromethyl)-4-pyridinyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913764

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Trifluoromethyl)pyridine-4-carboxylic acidHCID 14761447—
ReactantHCID 178509470HCID 178509470—
Product2-Cyclopropyl-4-(trifluoromethyl)-1-({5-[2-(trifluoromethyl)-4-pyridinyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrileHCID 86620723—

Reaction Steps

Synthesized as described in Example 72 from 2-[5-cyano-2-cyclopropyl-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide (Example 364A) and 2-(trifluoromethyl)-4-pyridinecarboxylic acid: MS (ES) m/z 478 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-2b1d0a603c17441aa5b6e14afe0391e9
Source noteuspto-grants-2011_09