HCID 87386553, compound → HCID 131729201, compound

HRID 913780Notes

Reaction equation

HRID 913780 reaction equation
[Na+].[C:2]1([CH2:8][C:9]([O:11][CH2:12][C:13]([F:19])([F:18])[S:14]([O-:17])(=[O:16])=[O:15])=[S:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na].FC(F)(F)S([O-])(=O)=O.[C:29]1([CH:35]([SH+:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[C:36]1([CH:35]([SH+:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1.[F:19][C:13]([F:18])([S:14]([OH:17])(=[O:16])=[O:15])[CH2:12][O:11][C:9](=[S:10])[CH2:8][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 87386553HCID 87386553, compoundHCID 131729198HCID 131729198, compound

Product 1

HCID 131729201HCID 131729201, compoundYield 98%

Procedure

<2> The reaction described in <3> of Synthesis Example 1 was performed under the same conditions, except that the phenylthioacetyloxymethyl difluoromethanesulfonic acid sodium salt (2.5 g) produced in <1> of Synthesis Example 6 above was used instead of the benzoyloxymethyldifluorosulfonic acid sodium salt in the reaction with diphenylmethylphenylsulfonium trifluoromethanesulfonic acid sodium salt, and thus 3.41 g (yield 98%) of phenylthioacetic acid 2,2-difluoro-2-sulfoethyl ester diphenylmethylphenylsulfonium salt as shown in the following reaction scheme 13 was obtained. The structure of the product was confirmed by 1H-NMR (see FIG. 12).

Workup

  1. custom<2> The reaction described in <3> of Synthesis Example 1
  2. customproduced in <1> of Synthesis Example 6

Sources & evidence

ORD record
ord-d76b9a86531b4e878afa423b51a3f78b
Source dataset
uspto-grants-2011_09
Patent number
US08026390B2

Reaction notes

Loading…