HCID 87386457, compound → HCID 131729202, compound

HRID 913781Notes

Reaction equation

HRID 913781 reaction equation
[Na+].[C:2]1([C:12]([O:14][CH2:15][C:16]([F:22])([F:21])[S:17]([O-:20])(=[O:19])=[O:18])=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.FC(F)(F)S([O-])(=O)=O.[C:31]1([CH:37]([SH+:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[C:38]1([CH:37]([SH+:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1.[F:22][C:16]([F:21])([S:17]([OH:20])(=[O:19])=[O:18])[CH2:15][O:14][C:12]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1)=[O:13]

Participants

3

Reactant 2

HCID 87386457HCID 87386457, compoundHCID 131729203HCID 131729203, compound

Product 1

HCID 131729202HCID 131729202, compoundYield 94.45%

Procedure

<2> The reaction described in <3> of Synthesis Example 1 was performed under the same conditions, except that the 1-naphthoyloxymethyl difluoromethanesulfonic acid sodium salt (2.61 g) produced in <1> of Synthesis Example 7 above was used instead of the benzoyloxymethyldifluorosulfonic acid sodium salt in the reaction with diphenylmethylphenylsulfonium trifluoromethanesulfonate salt, and thus 3.92 g (yield 94.45%) of 1-naphthoic acid 2,2-difluoro-2-sulfoethyl ester diphenylmethylphenylsulfonium salt as shown in the following reaction scheme 15 was obtained. The structure of the product was confirmed by 1H-NMR (see FIG. 14).

Workup

  1. custom<2> The reaction described in <3> of Synthesis Example 1
  2. customproduced in <1> of Synthesis Example 7

Sources & evidence

ORD record
ord-c7a94becbae243b9b01e8dd1fee83ecd
Source dataset
uspto-grants-2011_09
Patent number
US08026390B2

Reaction notes

Loading…