HCID 57546108, compound → HCID 57545969, compound

Participants

Reaction Steps

(±)-tert-Butyl 4-(4-fluorophenyl)-4-((1-(5-methyl-1H-indazol-7-yl)ethoxy)methyl)piperidine-1-carboxylate (35 mg, 0.075 mmol) was dissolved in trifluoroacetic acid (20% in dichloromethane, 2 mL) and stirred at room temperature for 30 min. The reaction was concentrated and loaded onto a strong cation exchange cartridge in methanol. The cartridge was flushed with several volumes of methanol which were discarded. The product was eluted with 2 M ammonia in methanol and concentrated to give 24 mg (87%). LC/MS (HPLC method 3): tR=2.658 min, 368.38(MH)+.

Provenance & Evidence