HCID 57546178, compound → HCID 57546093, compound

Participants

Reaction Steps

(±)-tert-Butyl 4-((1-(5-(dimethylamino)-1H-indazol-7-yl)ethoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate (138 mg, 0.278 mmol) was dissolved in trifluoroacetic acid (20% in dichloromethane, 7.5 mL) and stirred at room temperature for 30 min. The reaction was concentrated and loaded onto a strong cation exchange cartridge in methanol. The cartridge was flushed with several volumes of methanol which were discarded. The product was eluted with 2 M ammonia in methanol and concentrated to give 101 mg (92%). LC/MS (HPLC method 3): tR=1.133 min, 397.42(MH)+.

Provenance & Evidence