HCID 86626242, compound → HCID 67403196, compound

Participants

Reaction Steps

(±)-tert-Butyl 4-(4-fluorophenyl)-4-((1-(5-methoxy-1H-indazol-7-yl)methoxy)methyl)piperidine-1-carboxylate (20 mg, 0.041 mmol) was dissolved in trifluoroacetic acid (20% in dichloromethane, 1.5 mL) and stirred at room temperature for 30 min. The reaction was concentrated and loaded onto a strong cation exchange cartridge in methanol. The cartridge was flushed with several volumes of methanol which were discarded. The product was eluted with 2 M ammonia in methanol and concentrated to give 15 mg (95%). LC/MS (HPLC method 3): tR=2.387 min, 384.41(MH)+.

Provenance & Evidence