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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 91389Generated: October 25, 2026

Citric Acid → 6-fluoro-4-hydroxy-4-phenyl-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one

https://huagongshe.com/reaction/91389

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCitric AcidHCID 311—
ReactantButyl ChlorideHCID 8005—
ReactantTetrahydrofuranHCID 8028—
ReactantEthanamine, 2,2,2-trifluoro-HCID 9773—
ReactantPhosphorus oxide (P4O10)HCID 14812—
ReactantN-(2-benzoyl-4-fluorophenyl)-1H-imidazole-1-carboxamideHCID 21755401—
Product6-fluoro-4-hydroxy-4-phenyl-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-oneHCID 59346581—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
ORD IDord-c4cc8db656cb40ca9d492644f8b306de
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (2/10)