Cyclopropylboronic acid → HCID 25160970, compound

Participants

Reaction Steps

Suzuki coupling reaction of 6-Bromo-1-(cyclopropylmethyl)-2-(((1-methyl-4-phenylpiperidin-4-yl)methoxy)methyl)-1H-benzo[d]imidazole (12 mg, 0.026 mmol) with cyclopropylboronic acid (3 equiv.) following the procedure described for the synthesis of tert-butyl 4-(((5-(4-cyanophenyl)-1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate, gave 13 mg of the title compound (92% yield). LC/MS (HPLC method 8): tR=0.8 min, 430(MH)+.

Provenance & Evidence