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HRID914035

反应详情

EQUATION

反应方程式

HRID 914035 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CCC(COC(C(=O)O)c2cc(Cl)cc3cn[nH]c23)(c2ccc(F)cc2)CC1
HCID57546076

未命名化合物

结构：COC(=O)C(OCC1(c2ccc(F)cc2)CCN(C)CC1)c1cc(Cl)cc2cn[nH]c12.O=C(O)C(F)(F)F
HCID67403905

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCC(COC(C(=O)O)c2cc(Cl)cc3cn[nH]c23)(c2ccc(F)cc2)CC1.O=C(O)C(F)(F)F
HCID25161091

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure used to prepare methyl 2-(5-chloro-1H-indazol-7-yl)-2-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)acetate trifluoroacetic acid salt using 2-((1-(tert-butoxycarbonyl)-4-(4-fluorophenyl)piperidin-4-yl)methoxy)-2-(5-chloro-1H-indazol-7-yl)acetic acid as the starting material. 1H-NMR (CD3OD, 500 MHz) δ 8.06 (m, 1H), 7.78 (m, 1H), 7.35-7.53)m, 2H), 7.27 (d, J=1.5 Hz, 0.8H), 7.20 (d, J=1.5 Hz, 0.2H), 7.14 (m, 1.5H), 7.04 (m, 0.5H), 5.20 (s, 1H), 4.05 (d, J=9.5 Hz, 0.2H), 3.66 (d, J=9.2 Hz, 1H), 3.35-3.55 (m, 5H), 2.60-2.97 (m, 8H), 2.00-2.40 (m, 2.6H). Mass spec.: 432.21 (MH)+.

WORKUP

后处理

  1. customPrepared