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HRID914036

反应详情

EQUATION

反应方程式

HRID 914036 的结构方程式

REACTANTS

反应物

2
结构：CN(C)C(=O)C(OCC1(c2ccc(F)cc2)CCN(C(=O)OC(C)(C)C)CC1)c1cc(Cl)cc2cn[nH]c12
HCID57546179

未命名化合物

结构：COC(=O)C(OCC1(c2ccc(F)cc2)CCN(C)CC1)c1cc(Cl)cc2cn[nH]c12.O=C(O)C(F)(F)F
HCID67403905

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCC(COC(C(=O)N(C)C)c2cc(Cl)cc3cn[nH]c23)(c2ccc(F)cc2)CC1.O=C(O)C(F)(F)F
HCID25161094

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure used to prepare methyl 2-(5-chloro-1H-indazol-7-yl)-2-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)acetate trifluoroacetic acid salt using tert-butyl 4-((1-(5-chloro-1H-indazol-7-yl)-2-(dimethylamino)-2-oxoethoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate as the starting material. 1H-NMR (CD3OD, 500 MHz) δ 8.53 (m, 0.1H), 8.07 (m, 0.8H), 7.98 (m, 0.1H), 7.81 (m, 0.8H), 7.45 (m, 1.7H), 7.36 (m, 0.5H), 7.29 (m, 0.9H), 7.14 (dd, J=8.9, 8.5 Hz, 1.6H), 7.03 (dd, J=8.9, 8.9 Hz, 0.5H), 5.52 (s, 1H), 3.91 (d, J=9.2 Hz, 0.2H), 3.35-3.66 (m, 4H), 2.50-3.00 (m, 14H), 1.90-2.25 (m, 2H). Mass spec.: 459.26 (MH)+.

WORKUP

后处理

  1. customPrepared