HCID 57545991, compound → HCID 67405246, compound

HRID 914037Notes

Reaction equation

HRID 914037 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:10]=[C:11]2[C:15](=[C:16]([CH:18]([O:23][CH2:24][C:25]3([C:32]4[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=4)[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]3)[C:19](OC)=[O:20])[CH:17]=1)[NH:14][N:13]=[CH:12]2.ClC1C=C2C(=C(C(OCC3(C4C=CC(F)=CC=4)CCN(C(OC(C)(C)C)=O)CC3)CO)C=1)NN=C2>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:10]=[C:11]2[C:15](=[C:16]([CH:18]([O:23][CH2:24][C:25]3([C:32]4[CH:33]=[CH:34][C:35]([F:38])=[CH:36][CH:37]=4)[CH2:26][CH2:27][N:28]([CH3:31])[CH2:29][CH2:30]3)[CH2:19][OH:20])[CH:17]=1)[NH:14][N:13]=[CH:12]2

Participants

3

Reactant 2

HCID 57545991HCID 57545991, compoundHCID 67403905HCID 67403905, compound

Product 1

HCID 67405246HCID 67405246, compound

Procedure

Prepared according to the procedure used to prepare methyl 2-(5-chloro-1H-indazol-7-yl)-2-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)acetate trifluoroacetic acid salt using tert-butyl 4-((1-(5-chloro-1H-indazol-7-yl)-2-hydroxyethoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate as the starting material. 1H-NMR (CD3OD, 500 MHz) 6 8.05 (m, 1H), 7.73 (m, 1H), 7.40 (m, 2H), 6.85-7.20 (m, 3H), 4.65 (m, 1H), 3.77 (m, 1.6H), 3.49 (m, 3.8H), 2.40-3.00 (m, 7H), 2.13 (m, 2H). Mass spec.: 418.24 (MH)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-46c334bb92f64fadad1f62ab2c70e6b9
Source dataset
uspto-grants-2011_09
Patent number
US08026257B2

Reaction notes

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