HCID 57546214, compound → 5-Chloro-7-(1-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)-2-methoxyethyl)-1h-indazole trifluoroacetic acid salt

HRID 914038Notes

Reaction equation

HRID 914038 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:10]=[C:11]2[C:15](=[C:16]([CH:18]([O:23][CH2:24][C:25]3([C:32]4[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=4)[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]3)[C:19]([O:21][CH3:22])=O)[CH:17]=1)[NH:14][N:13]=[CH:12]2.ClC1C=C2C(=C(C(OCC3(C4C=CC(F)=CC=4)CCN(C(OC(C)(C)C)=O)CC3)COC)C=1)NN=C2>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:10]=[C:11]2[C:15](=[C:16]([CH:18]([O:23][CH2:24][C:25]3([C:32]4[CH:33]=[CH:34][C:35]([F:38])=[CH:36][CH:37]=4)[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]3)[CH2:19][O:21][CH3:22])[CH:17]=1)[NH:14][N:13]=[CH:12]2

Participants

3

Reactant 2

HCID 57546214HCID 57546214, compoundHCID 67403905HCID 67403905, compound

Product 1

HCID 251610965-Chloro-7-(1-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)-2-methoxyethyl)-1h-indazole trifluoroacetic acid salt

Procedure

Prepared according to the procedure used to prepare methyl 2-(5-chloro-1H-indazol-7-yl)-2-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)acetate trifluoroacetic acid salt using tert-butyl 4-((1-(5-chloro-1H-indazol-7-yl)-2-methoxyethoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate as the starting material. 1H-NMR (CD3OD, 500 MHz) δ 8.48 (s, 0.1H), 8.03 (s, 0.8H), 7.88 (s, 0.1H), 7.70 (m, 0.8H), 7.42 (m, 2H), 6.90-7.40 (m, 3H), 4.77 (m, 1H), 3.87 (m, 0.3H), 3.68 (m, 1H), 3.40-3.63 (m, 4.8H), 2.40-3.00 (m, 7H), 2.12 (m, 2H). Mass spec.: 432.26 (MH)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-36a0f492760444e58dce78dd4335e52d
Source dataset
uspto-grants-2011_09
Patent number
US08026257B2

Reaction notes

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