1-Amino-4-methylpiperazine → HCID 57955547, compound

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Reaction Steps

The title compound was synthesized from 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and 4-methylpiperazin-1-amine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.59-1.64 (m, 4H) 1.67-1.75 (m, 2H) 1.89-1.97 (m, 2H) 2.79 (d, J=4.6 Hz, 3H) 3.11-3.30 (m, 6H) 3.32 (s, 3H) 3.44 (d, J=12.6 Hz, 2H) 3.93 (s, 3H) 4.09 (t, J=13.9 Hz, 2H) 4.76-4.81 (m, 1H) 7.46 (d, J=8.3 Hz, 1H) 7.48 (s, 3H) 8.24 (d, J=8.34 Hz, 1H) 8.27 (s, 1H) 9.79 (s, 1H). Melting point: 168-174° C. [M+H] calc'd for C26H34F2N8O3, 545. found 545.

Provenance & Evidence