1-Pyrrolidinamine → HCID 25253220, compound

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Reaction Steps

The title compound was synthesized from 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and pyrrolidin-1-amine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.43-1.75 (m, 6H) 1.90-2.02 (m, 2H) 2.67-3.03 (m, 4H) 3.57 (s, 3H) 3.95 (s, 3H) 4.05 (t, 2H) 4.73-4.81 (m, 1H) 7.48-7.54 (m, 2H) 8.00 (s, 1H) 8.20 (d, 1H) 8.27 (s, 1H) 8.30 (d, 1H). [M+H] calc'd for C25H31F2N7O3, 516. found 516.

Provenance & Evidence