4-[2-(Dimethylamino)ethoxy]aniline → HCID 25253369, compound

Participants

Reaction Steps

The title compound was synthesized using an analogous procedure to that described in connection with 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid from 2-Chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one and 4-(2-(dimethylamino)ethoxy)aniline. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.44-1.79 (m, 6H) 1.93 (br. s, 2H) 2.20 (s, 6H) 2.59 (t, J=5.81 Hz, 2H) 3.32 (s, Hz, 3H) 3.88-4.10 (m, 4H) 4.68 (t, J=8.34 Hz, 1H) 6.85 (d, J=8.84 Hz, 2H) 7.55 (d, J=9.09 Hz, 2H) 8.18 (s, 1H) 9.20 (s, 1H). [M+H] calc'd for C23H30F2N6O2, 461. found 461.

Provenance & Evidence