6-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one → HCID 25253370, compound

Participants

Reaction Steps

The title compound was synthesized using an analogous procedure to that described in connection with 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid from 2-Chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one and 6-amino-2H-benzo[b][1,4]oxazin-3(4H)-one. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.48-1.80 (m, 6H) 1.95 (br. s, 2H) 3.40 (s, 3H) 4.01 (t, J=14.15 Hz, 2H) 4.52 (s, 2H) 4.72 (t, J=8.08 Hz, 1H) 6.77 (d, J=8.34 Hz, 1H) 7.20 (dd, J=8.59, 2.02 Hz, 1H) 7.46 (d, J=2.27 Hz, 1H) 8.20 (s, 1H) 9.35 (s, 1H) 10.54 (br. s., 1H) [M+H] calc'd for C21H22F2N6O3, 445. found 445.

Provenance & Evidence