HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-4-methylpiperazine → HCID 25253838, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-4-methylpiperazine | HCID 81349 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-benzoic acid | HCID 25253680 | — |
| Product | HCID 25253838 | HCID 25253838 | — |
Reaction Steps
The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and 1-amino 4-methylpiperazine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.20-1.85 (m, 10H) 2.18 (s, 3H) 2.93 (br. s., 3H) 3.22-3.47 (m, 7H) 3.93 (s, 3H) 4.06 (t, J=13.39 Hz, 2H) 4.46 (m, 1H) 7.44 (br. s., 1H) 7.42 (d, J=8.84 Hz, 1H) 7.90 (s, 1H) 8.21 (s, 1H) 8.27 (d, J=8.08 Hz, 1H) 9.40 (s, 1H). [M+H] calculated for C27H36F2N8O3, 559. found 559.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026234B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-947f436fc1ee4a4f936b45f15eccb0d7 |
| Source note | uspto-grants-2011_09 |