反应详情

The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and N1,N1-dimethylcyclohexane 1,4-diamine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.11-1.96 (m, 18H) 2.17 (s, 6H) 3.31 (s, 3H) 3.73 (m, 1H) 3.92 9m, 1H) 3.94 (s, 3H) 4.06 (t, J=13.52 Hz, 2H) 4.46 (m, 1H) 7.42-7.59 (m, 2H) 7.89 (s, 1H) 8.11 (m, 1H) 8.21 (s, 1H) 8.26 (d, J=8.34 Hz, 1H). Melting point: 208-214° C. [M+H] calculated for C30H41F2N7O3, 586. found 586.

1. customas described in the General procedure for amide bond synthesis
2. customThe final compound was purified by reverse phase HPLC
3. customto give the free base