1,1-Dimethylhydrazine → HCID 25254460, compound

Participants

Reaction Steps

The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and N,N-dimethyl-hydrazine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.15-1.43 (m, 2H) 1.53-1.92 (m, 8H) 2.92 (s, 6H) 3.32 (s, 3H) 3.96 (s, 3H) 4.14 (t, J=13.0 Hz, 2H) 4.42-4.52 (m, 1H) 7.44-7.52 (m, 2H) 8.20-8.27 (m, 2H) 8.49 (br. s., 1H). [M+H] calc'd for C24H31F2N7O3 504. found 504.

Provenance & Evidence