HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 914157Generated: October 27, 2026
2486-69-3 → 4-(9-Cyclohexyl-7-fluoro-5,7-dimethyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid
https://huagongshe.com/reaction/914157
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2486-69-3 | HCID 288057 | — |
| Reactant | 2-Chloro-9-cyclohexyl-7-fluoro-5,7-dimethyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one | HCID 57955656 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(9-Cyclohexyl-7-fluoro-5,7-dimethyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid | HCID 57955535 | 32% |
Reaction Steps
A mixture of 2-chloro-9-cyclohexyl-7-fluoro-5,7-dimethyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one (330 mg, 1 mmol), 4-amino-3-methoxybenzoic acid (184 mg, 1.1 mmol), isopropanol (10 ml), and concentrated hydrochloric acid (10 drops) was stirred at 100° C. for 20 h. Solid was filtered to give 146 mg product as white solid (32%). [M+H] calc'd for C23H28FN5O4, 458. found 458.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08026234B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-a03988da2c1847e89dd2e5ad72cc82f5 |
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| Source note | uspto-grants-2011_09 |
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