Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 25253070, compound

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Reaction Steps

The title compound was synthesized from 4-(9-cyclohexyl-7-fluoro-7-vinyl-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and 1-methylazetidin-3-amine bis-hydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.48-2.10 (m, 8H) 2.32 (br. s., 3H) 3.08 (t, J=6.82 Hz, 2H) 3.29 (br. s., 3H) 3.62 (t, J=6.95 Hz, 2H) 3.82 (m, 2H) 3.94 (br. s., 3H) 4.44 (m, 1H) 4.88 (m, 1H) 5.38 (d, J=12.13 Hz, 2H) 5.99 (m, 1H) 7.50 (br. s., 2H) 7.84 (br. s., 1H) 8.13 (br. s., 1H)) 8.31 (d, J=8.0 Hz, 1H) 8.65 (d, J=7.83 Hz, 1H). [M+H] calculated for C27H34FN7O3, 524. found 524.

Provenance & Evidence